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1984 (1)
1979 (1)
1Author    Karl Eisele, Fernando Dias Costa, Carlos Pascual, BeatusO. Fenloch-HähnleRequires cookie*
 Title    A Simple Method to Prepare Affinity Resins on Cellulose Basis  
 Abstract    Affinity resins with different spacer arms were synthesized analogues to the solid phase peptide synthesis using aminoethyl cellulose or carboxym ethyl cellulose as matrix. The spacer arms could be varied in length and rigidity. Especially spacer arms consisting o f poly am ino acids can be synthesized with a defined amount o f am ino acid residues specifically in the low molecular weight ranges. The method is also applicable to other matrices w hich are not susceptible to 1 N HC1 in glacial acetic acid, trethylamine, m ethylene chloride and dim ethylform am ide. The synthesis o f affinity resins with different spacer arms for the purification o f androgen receptors is described as an exam ple o f the method. 
  Reference    Z. Naturforsch. 39c, 1048—1051 (1984); received August 8 1984 
  Published    1984 
  Keywords    Affinity Resins, Solid Phase Peptide Synthesis, C ellulose, Androgen Receptor 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-1048.pdf 
 Identifier    ZNC-1984-39c-1048 
 Volume    39 
2Author    Frank Seela, Johann Ott, Helmut RosemeyerRequires cookie*
 Title    Immobilisierung von Adenosinacetalen mit variablem Alkylidenrest — die Funktion des Spacers bei enzymatischer Desaminierung Immobilization of Adenosine-Acetals with Variable Alkylidene Residues — the Function of the Spacer during Enzymatic Deamination —  
 Abstract    Acetalation of the cis-diol moiety of adenosine or inosine with aliphatic ketoesters of different chain lengths leads to alkylidene derivatives of the nucleosides, which differ in the number of methylene groups in the hydrocarbon chain. By alkaline hydrolysis of the ester group in l a — c or 3 a —c the corresponding acids 2 a —c and 4 a —c have been prepared. The configuration of the new chiral centres has been determined as R. Enzymatic deamination of the alkylidene derivatives of adenosine leads to the inosine compounds. The rate of deamination reaction is raised by an increasing number of methylene groups in the alkylidene residues or by use of the esters instead of the acids. The alkylidene derivatives of adenosine were coupled with 6-aminohexylagarose yielding polymers with adenosine as ligands. No enzymatic deamination of the polymer with the shortest spacer was observed. The polymers with the longer spacers were converted to the corresponding inosine derivatives. The velocity of the deamination reaction was raised by an increasing spacer length. 
  Reference    Z. Naturforsch. 34c, 350—358 (1979); eingegangen am 30. 12. 1978/12. 2. 1979 
  Published    1979 
  Keywords    Cyclic 0-2', 3'-Adenosine-acetals, Affinity Resins, Spacer, Adenosine Deaminase 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0350.pdf 
 Identifier    ZNC-1979-34c-0350 
 Volume    34