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1980 (1)
1Author    Georg Rampold, Elsa Lundanes, Karl Folkers, Wolfgang Voelter, Hubert Kalbacher+, Emile BliznakovRequires cookie*
 Title    Solid Phase Synthesis of Thymopoietin-(32-36) Using Adpoc Amino Acids and its Biological Activity +  
 Abstract    An exemplary peptide has been synthesized for the first time by an automated solid-phase instrumentation which utilized the new Adpoc (1 -(1-adamantyl) -1 -methylethoxycarbonyl-) group for protection of the a-amino groups of the amino acids. The pentapeptide, thymo-poietin-(32-36) was synthesized, and shown to be pure by criteria including HPLC. Using a Cytoxan (cyclophosphamide) model system for suppression of a primary, hemolytic, humoral, antibody level, thymopoietin-(32-36) showed low activity, and reversed the suppressing effect of Cytoxan. This biological activity apparently is the result of cum-mulative effect. 
  Reference    Z. Naturforsch. 35b, 1476—1478 (1980); received May 27 1980 
  Published    1980 
  Keywords    Adpoc Amino Acids, Solid Phase Synthesis, Thymopoietin-(32-36) 
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 TEI-XML for    default:Reihe_B/35/ZNB-1980-35b-1476.pdf 
 Identifier    ZNB-1980-35b-1476 
 Volume    35