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1978 (1)
1Author    Hans-Helmut Paul, Helmut Sapper, Wolfgang LohmannRequires cookie*
 Title    H -N M R Investigations on the Hydrogen Bond Formation between the Tranquilizers Diazepam and Nitrazepam and Some Nucleobases  
 Abstract    The form ation of hydrogen bonds between the minor tranquilizers diazepam and nitrazepam and a few nucleobases was studied in deuterochloroform solution by means of proton m agnetic resonance spectroscopy. The therm odynam ic and spectroscopic data of the associations were evaluated on the basis of a dim er model, using the concentration dependent shifts of the protons involved in hydrogen bonds. The interactions of nitrazepam (Zl//0= —10 to —21 k j/m o l; AG°25 — 0 . 2 to —7.4 kj/m ol) were found to be stronger than those of diazepam (A H ° = — 1 0 to — 13 k j/m o l; A G ls = 6.0 to 6.4 k j/m o l). The various binding sites of the benzodiazepines for hydrogen bonds are discussed. 
  Reference    Z. Naturforsch. 33c, 870 (1978); received June 16/Septem ber 14 
  Published    1978 
  Keywords    1978 1, 4-Benzodiazepines, Hydrogen Bonding, Nucleobases, Dimer Model 
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 TEI-XML for    default:Reihe_C/33/ZNC-1978-33c-0870.pdf 
 Identifier    ZNC-1978-33c-0870 
 Volume    33