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'3 Butanedione' in keywords Facet   Publication Year 1979  [X]
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1Author    Dorothee Petz, H. Ans-G, Erhard Löffler, Friedh SchneiderRequires cookie*
 Title    Inhibition of E. coli l -Asparaginase by Reaction with 2,3-Butanedione. Chemical Modification of Arginine and Histidine Residues  
 Abstract    The inactivation o f E. coli asparaginase by 2,3-butanedione studied with L-asparagine and dia-zooxonorvaline as substrates obeys pseudo first order kinetics. Activity losses are linear with re­ spect to arginine and histidine m odification, with com plete inactivation being correlated with alter­ ation o f one arginine and one histidine per subunit. The rate o f inactivation o f the enzym was re­ duced in the presence o f com petitive inhibitors like L-2-am ino-2-carboxyethane-sulfonam ide. U n ­ der comparable conditions 1,2-cyclo hexanedione does not affect the activity o f L-asparaginase. 
  Reference    Z. Naturforsch. 34c, 742 (1979); received May 8 1979 
  Published    1979 
  Keywords    Asparaginase, 2, 3-Butanedione, Arginine and Histidine Residues 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0742.pdf 
 Identifier    ZNC-1979-34c-0742 
 Volume    34