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1988 (1)
1Author    Kaeko Kikuchi, Yoshio Taniyama, Ryuji MarumotoRequires cookie*
 Title    Evaluation of the 2 NH 2 A—T Pair in Hybridization, I Synthesis of the DNA/RNA Hybrid Oligomers Containing 2-Aminoadenosines  
 Abstract    DNA decamers containing 2-aminoadenosine were synthesized. Oligonucleotide duplexes in-cluding the 2 NH2A—T base pairs were prepared and their Tm profile examined. Contrary to expectation, elevation of the Tm value by the 2 NH2 group is very small in DNA/RNA duplexes. From the CD spectra measurement, we assume that the distortion of the B-DNA structure caused by scattered DNA/RNA base pairing diminishes the efficient hydrogen bonding and base stacking of the duplexes. It was also found that the DNA duplexes containing 2-aminoadenosine hybrids are considerably resistant to ribonuclease T2 or nuclease PI digestion. 
  Reference    Z. Naturforsch. 43b, 623—630 (1988); received October 12 1987/February 1 1988 
  Published    1988 
  Keywords    DNA Probe, Hybridization, 2-Aminoadenosine, CD Spectra, DNA/RNA Hybrid Oligomer 
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 TEI-XML for    default:Reihe_B/43/ZNB-1988-43b-0623.pdf 
 Identifier    ZNB-1988-43b-0623 
 Volume    43