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1995 (1)
1Author    Dagmar Holthenrich, Imre Sóvágó, G. Erd Fusch, Andrea Erxleben, EddaC. Fusch, Ingo Rombeck, B.Ernhard LippertRequires cookie*
 Title    Heteronuclear Nucleobase Complexes as Tools for the Isolation of the Minor Rotamer of the Parent Compound: Synthesis and Crystal Structure Determination of H ead-H ead and H ead-Tail Forms of rrfl«5-[(CH3NH2)2Pt(l-MeC-Ar J)2]2+ (1-MeC = 1-methylcytosine)  
 Abstract    The two rotamers (head-tail, 1, and head-head, 2) of the bis(l-m ethylcytosine)com plex of f/ww-(CH3N H 2)2Pt(II), have been crystallized as C104-(1, 2a) and PF6-(2b) salts and characterized by X-ray crystal structure analysis and 'H and 19:iPt NMR spectroscopy. In aqueous solution, 1 is preferred over 2 by 70:30. Upon slow crystallization from H 2Ö, 1 is obtained as the only product. Isolation of 2a and 2b has now been accomplished via forma­ tion of the heteronuclear derivative rrans-[(CH3N H 2)2Pt(l-MeCv/V3,./W)2Hg]2+, in which the deprotonated 1-methylcytosinato ligands (1 -M eC) are oriented head-head, precipitation of Hg(II) by thiourea, and rapid crystallization of the parent compound. The solid state struc­ tures of 1 and 2b differ markedly in a number o f aspects. Isolation of pure 1 and 2 permits a detailed study of the kinetics and thermodynamics of the interconversion of the two rotam­ ers. From comparison with the behavior of 1 and 2 in H20 on the one hand and DM SO and DM F on the other a clear solvent effect on the rotamer distribution is seen which most likely relates to differences in H bonding between solvent and solute. 
  Reference    Z. Naturforsch. 50b, 1767—1775 (1995); received May 15 1995 
  Published    1995 
  Keywords    Transplatin, Nucleobase, 1-Methylcytosine, R otation, X-Ray 
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 TEI-XML for    default:Reihe_B/50/ZNB-1995-50b-1767.pdf 
 Identifier    ZNB-1995-50b-1767 
 Volume    50