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Facet Publication Year 1980 [X]
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1	Author	L. Cassidei, A. Dell 'atti, O. Sciacovelli	Requires cookie*
	Title	A Spectroscopic Study on p-Hydroxyphenylpyruvic Acid. Keto-Enol Tautomerism and Stability of Its Complex with Fe+3 Ions
	Abstract	p-H ydroxyphenylpyruvic Acid, Tautom erism , Complex Stability o f pH PPA -FeC l3 *H-, 13C -N M R , IR, U V -V is, and M S spectra o f />-hydroxyphenylpyruvic acid (pH PPA) have been recorded and fully interpreted. pHPPA exists in solution as a mixture o f interconverting forms: keto, hydrated keto and only one enol tautomer to which the Z configuration has been assigned according to the value (3.7 Hz) o f the vicinal IH -C = C -13COOH coupling constant. In organic solvents the enol isomer is far more stable whereas in aqueous solutions the keto form predominates. The tautomeric equilibrium is pH-dependent and the anion is present as keto form not only in aqueous solution but also in H zO -DM SO mixtures with a high content o f DMSO. The Z enol tautomer does form a coloured com plex (Amax = 680 nm) with F e+3 ions. The com plex decom poses rapidly in all considered solvents except DMSO. In view o f a possible use o f H20 -D M S 0 mixtures for clinical analysis purpose, the enol fraction o f pHPPA and the stability o f the pH PPA -FeC l3 com plex in H 20 -D M S 0 mixtures have been examined. Our results suggest that a solvent com position containing at least 80 vol.% in DM SO could be an appropriate solvent for pH PPA determination by FeC l3 method.
	Reference	Z. Naturforsch. 35c, 1—5 (1980); received July 20 /0 cto b er 15 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0001.pdf
	Identifier	ZNC-1980-35c-0001
	Volume	35

2	Author	G. J. Louter, P.F M Stalmeier, A.J H Boerboom, J. Haverkamp, J. Kistemaker	Requires cookie*
	Title	High Sensitivity in CID Mass Spectrometry, Structure Analysis of Pyrolysis Fragments
	Abstract	Collision Induced D issociation (C ID),C ollisional Activation (CA), Pyrolysis, Mycobacterium, Mass Spectrometry An apparatus is described for Collision Induced Dissociation Mass Spectrometry, where es sential increase in sensitivity in the detection o f the fragment spectrum is obtained by sim ultaneous detection. Decrease in resolution due to kinetic energy release on dissociation is prevented by post-acceleration o f the fragment ions. The instrument was used to investigate the structure o f the mass m /z = 59 com pound in the pyrolysis products o f M ycobacterium cells. This mass is a key mass in the pyrolysis mass spectrometric identification o f dangerous mycobacterial strains.
	Reference	Z. Naturforsch. 35c, 6 (1980); received October 30 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0006.pdf
	Identifier	ZNC-1980-35c-0006
	Volume	35

3	Author	V. Rutar, R. Blinc	Requires cookie*
	Title	Nondestructive Determination of Protein Content of Viable Seeds by Proton Enhanced 13C NMR
	Abstract	13C, N M R , Protein Content, Seeds Proton enhanced 13C N M R spectroscopy was used for a non-destructive determination o f the protein content in single viable soybean, horse-bean, bean and com seeds. The intense 13C oil lines were suppressed by a series o f saturating pulses and spin temperature reversal so that only the 13C protein and carbohydrate signals o f the solid part o f the seed were detected. Significant seed to seed variations in the protein content were found which can be used as a basis for rapid seed selection in plant breeding programs.
	Reference	Z. Naturforsch. 35c, 12 (1980); received September 1 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0012.pdf
	Identifier	ZNC-1980-35c-0012
	Volume	35

4	Author	Naaman Akavia, Dieter Strack	Requires cookie*
	Title	High Performance Liquid Chromatography of Anthocyanidins as a New Approach to Study Flower Pigment Genetics
	Abstract	The described m ethod allows rapid screening and accurate quantification o f anthocyanidins with the aid o f HPLC. Using a linear gradient in 40 m in from 20 to 40% o f solvent B (1.5% phosphoric acid -20% acetic acid — 25% acetonitrile) in solvent A (1.5% phosphoric acid) + B on LiChrosorb RP-8 the com m on six anthocyanidins delphinidin, cyanidin, petunidin, pelargonidin, peonidin, and m alvidin were resolved within 40 min. It is demonstrated that acetonitrile is superior to other solvents in resolving m ethoxylated phenolic compounds. The application o f the described m ethod is shown with Gladiolus petals in studies o f flower pigm ent genetics.
	Reference	Z. Naturforsch. 35c, 16 (1980); received October 8 1979
	Published	1980
	Keywords	H igh Performance Liquid Chromatography, Anthocyanidins, Gladiolus, Iridaceae, G enetics
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0016.pdf
	Identifier	ZNC-1980-35c-0016
	Volume	35

5	Author	Wolfgang Flossmann, Herbert Zehner, Adolf Müller	Requires cookie*
	Title	Radicals Produced in Single Crystals of Thymine Derivatives by UV and X-Rays
	Abstract	Single crystals o f anhydrous thym ine (T), thym ine monohydrate (T ■ H 20) , 5,6-dihydrothym ine (T H 2), 1-methylthymine (mT) and thym idine (dT) were irradiated with X-rays and UV between 77 K and 300 K. Six types o f radicals were analyzed by ESR-spectroscopy at 9.5 G H z and 35 G H z after exposure to X-rays. The anion radical occurred only in T • H 20 at 77 K, the 4-yl radical only in T H 2 at 77 K and the 1-yl radical only in T between 77 K and 300 K. The 6 -yl radical was found in T, T H 2 and mT. It was converted into the 5-yl radical irreversibly by heat or white light (A < 600 nm). The 5-yl radical appeared in all compounds at room temperature. The highest thermal stability was found for the 7-yl radical which was present at room temperature in all compounds except T H 2 . U V -irradiation (A = 320 nm) produced radicals only in three crystals (T, T H 2 , dT). In T the 5-yl radical was found after exposure at 300 K, and two other radicals, 1-yl and 7-yl, at 77 K. A lso at 77 K, the 7-yl radical was present in dT and the 5-yl radical in TH 2 and dT.
	Reference	Z. Naturforsch. 35c, 20—2 (1980); received July 23 1979
	Published	1980
	Keywords	Radicals, Single Crystals, Thym ine, X-Rays, ESR
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0020.pdf
	Identifier	ZNC-1980-35c-0020
	Volume	35

6	Author	Zygmunt Kazimierczuk, Lech Dudyczb, Ryszard Stolarskia, David Shugara	Requires cookie*
	Title	Preparation of 1-a-D-Arabinofuranosylbenzimidazole and Its 5,6-Dichloro Derivative, and the Direct Bromination of Benzimidazole Nucleosides
	Abstract	Arabinofuranosyl Benzim idazole N ucleosides, Direct Bromination o f Benzim idazole N ucleosides, 'H N M R Spectroscopy, Ultraviolet Spectra The 1-a-D-arabinofuranosides o f benzim idazole and 5,6-dichlorobenzim idazole, analogues o f the biologically active 5,6-dichloro-l-/?-D-ribofuranosylbenzim idazole, have been synthesized by condensation o f the trimethylsilyl derivative o f the appropriate benzim idazole in the presence o f SnCl4 with l-0-m ethyl-2,3,5-tribenzoyl-a-D -arabinoside. The 5(6)-m onobrom o and the 5,6-dibrom o derivatives o f l-/?-D-ribofuranosylbenzimidazole and 1-a-D-arabinofuranosylbenzimidazole were then prepared by direct bromination o f the latter. With l-/?-D-ribofuranosylbenzimidazole, the initial product o f bromination was a 1:1 mixture o f the 5-bromo and 6 -brom o derivatives; the final product was the desired 5,6-dibromo analogue. In the case o f 1 -ar-D-arabinofuranosylbenzimidazole, the initial product o f bromination was the 5-(or 6 -)brom o derivative, and the 5,6-dibrom o derivative the final product. The monobrom o derivatives were easily separated from the dibrom o by chromatography on Am berlite X A D-4. Identification o f all o f these was based on several criteria, including detailed analyses o f the *H N M R spectra. The benzim idazole nucleoside are considerably m ore resistant to acid hydrolysis than the cor responding purine nucleosides. The effects o f halogenation on the ultraviolet absorption spectra o f the benzim idazole nucleosides are described.
	Reference	Z. Naturforsch. 35c, 30 (1980); received July 31 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0030.pdf
	Identifier	ZNC-1980-35c-0030
	Volume	35

7	Author	VolkerH. Dietz, Eckhard Wollenweber, Jean Favre-Bonvin, LuisD. Gómez, P.	Requires cookie*
	Title	A Novel Class of Complex Flavonoids from the Frond Exudate of Pityrogramma trifoliata
	Abstract	Fronds o f the neotropical fern Pityrogram m a trifoliata produce a farinose exudate which consists mainly o f a dihydrochalcone. The structure o f som e minor constituents has been elucidated by spectroscopic m ethods. They are shown to be representatives o f a novel class o f complex flavonoids, com posed o f a flavonoid and a neoflavonoid moiety. In other terms, they are 5,7-di-hydroxy-8-cinnam oyl-4-phenyl-dihydrocoum arins. The occurence o f these and closely related compounds in this fern's exudate supports its inclusion in the genus Pityrogramma.
	Reference	Z. Naturforsch. 35c, 36—4 (1980); received Septem ber 25 1979
	Published	1980
	Keywords	Pityrogramma trifoliata, Polypodiaceae, Farinose Exudate, Com plex Flavonoids, Cinnamoyl-phenyl-dihydrocoumarins
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0036.pdf
	Identifier	ZNC-1980-35c-0036
	Volume	35

8	Author	B. Kopp, W. Löffelhardt	Requires cookie*
	Title	Determination of Progesterone in Vegetative Organs and Cell Organelles of ConvaUaria majalis L. by Radioimmunoassay
	Abstract	Progesterone was extracted from leaves and subterranean parts o f Convallaria majalis L. and quantified by radioimmunoassay. During the stage o f flowering the content o f progesterone in rhizomes was by a factor o f four higher than in leaves and by a factor o f ten higher than in roots, whereas five weeks later the level o f progesterone was unchanged in rhizomes and roots but was elevated in the leaves. The change in progesterone distribution is discussed in relation to the development o f the plants. At the subcellular level the mitochondrial and microsomal fractions contained the largest quantity o f progesterone in leaf cells. However, significant amounts were also found in the 2 0 0 0 x g fraction com prising nuclei and chloroplasts.
	Reference	Z. Naturforsch. 35c, 41 (1980); received N ovem ber 14 1979
	Published	1980
	Keywords	Convallaria majalis L, Progesterone Determ ination, Organs, Subcellular Distribution, R adio immunoassay
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0041.pdf
	Identifier	ZNC-1980-35c-0041
	Volume	35

9	Author	D. L. Struble, H. Am, H. R. Buser, E. Städler, J. Freuler	Requires cookie*
	Title	Identification of 4 Sex Pheromone Components Isolated from Calling Females of Mamestra brassicae W ein-und G artenbau, CH-8820 Wädenswil
	Abstract	on transfer o f work (1 9 7 7 -7 8) at Eidg. Forschungsanstalt für Obst-, W ein-und Gartenbau, CH-8820 Wädenswil
	Reference	Z. Naturforsch. 35c, 45—4 (1980); received O ctober 9 1979
	Published	1980
	Keywords	Sex Pheromone, (Z )-l 1-Hexadecenyl Acetate, Pherom one Inhibitors, M am estra brassicae, Calling Females
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0045.pdf
	Identifier	ZNC-1980-35c-0045
	Volume	35

10	Author	Franz Dallacker, Germanus Reichrath, Gerard Schnackers	Requires cookie*
	Title	Über eine durch Benzo-und Naphtho[1.3]dioxolcarbonsäuren an Mäusen erzeugbare Krampfwirkung Spasm-Activity Caused by Interaction of Benzo-and Naphtho-1.3-Dioxole-carboxylic Acids of Mice
	Abstract	Extension-Spasm, B enzo[l,3]dioxole-5-carb oxylic A cid, Benzo[l,3]dioxole-4-carboxylic Acid, N aphtho [ 1,3] dioxole-carboxylic A cids
	Reference	Z. Naturforsch. 35c, 49 (1980); eingegangen am 24. Juli 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0049.pdf
	Identifier	ZNC-1980-35c-0049
	Volume	35

11	Author		Requires cookie*
	Title	P1, P3-(5'-Guanosyl-5"-[14C] adenosyl) triphosphat: Darstellung der Kappenmutterverbindung sowie deren Abbauverhalten gegenüber subzellulären Fraktionen der Rattenleberzelle
	Reference	Z. Naturforsch. 35c, 57 (1980)
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0057.pdf
	Identifier	ZNC-1980-35c-0057
	Volume	35

12	Author	Wolf Strecker, Siegfried Silz, Gerhard Ruhenstroth-Bauer, Ingolf Böttger	Requires cookie*
	Title	Insulin und Glukagon im Blutplasma teilhepatektomierter Ratten Insulin and Glucagon in the Blood Plasma of Partial Hepatectomized Rats
	Abstract	U p to 4 weeks after partial hepatectomy the concentrations o f im m unoreactive insulin and glucagon in the blood plasma of rats were determined. Furtherm ore we m easured the activity of acid phosphatase in the serum, the concentration of cyclic AM P in liver cells, the activities of acid phosphatase in whole liver cells and in the cytosol of liver cells after partial hepatectomy. 2 h after partial hepatectom y there was a decline of the concentration o f insulin in the plasm a to about 13% of the initial value. 12 h after surgery a 5-fold increase of glucagon was found in the plasma. Shortly after this cyclic AMP reached its highest concentration. The activity of acid phosphatase in the whole liver cells and in the cytosol decreases slightly in the first 24 h after surgery whereas there is an increase o f the activity of acid phosphatase in the serum.
	Reference	Z. Naturforsch. 35c, 65—7 (1980); eingegangen am 2. M ärz/2. August 1979
	Published	1980
	Keywords	Rat, Partial Hepatectomy, Blood Plasma, Glucagon, Insulin
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0065.pdf
	Identifier	ZNC-1980-35c-0065
	Volume	35

13	Author	Qamar Khalid, M.Ataur Rahman	Requires cookie*
	Title	Studies on Synergism between Glucose and Amino Acids with Respect to Insulin Release in vitro
	Abstract	The mutual enhancement of the effect of insulin release by glucose and amino acids is not clearly understood. Present in vitro studies with isolated rat islets were undertaken to elaborate the role of amino acids on insulin release, particularly their interaction with glucose as well as among each other, which has been reported to lead to synergism in the hum an subjects. In the presence of 8.3 mM glucose, both arginine, as well as, leucine potentiated the effect of glucose which increased progressively with the increasing concentrations of the amino acid. This effect of arginine was not synergistic in nature because arginine did not stimulate insulin release in the absence of glucose. The effect of glucose and leucine was found to be additive and not synergistic. No synergism was exhibited by any o f the am ino acid pairs tested in the present study. Thus both phenylalanine and lysine did not potentiate the effect o f either arginine or leucine. Arginine showed a mild, but significant potentiating effect on leucine-stimulated insulin release. It is suggested that synergism between glucose and amino acids and between certain am ino acid pairs reported in m an may not be due to the direct effects of these stimuli on the beta cells, but some other factors in vivo may be involved.
	Reference	Z. Naturforsch. 35c, 72—7 (1980); received September 3 1979
	Published	1980
	Keywords	Insulin Release, Glucose, Amino Acids, Synergism, Rat Islets
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0072.pdf
	Identifier	ZNC-1980-35c-0072
	Volume	35

14	Author	Erwin Schauenstein, Wolfram Saenger, RudolfJörg Schaur, Gemot Desoye, Wolfgang Schreibmayer, N.	Requires cookie*
	Title	Der Einfluß des pH, der Temperatur und der Polarität des Lösungsmittels auf die Absorption des reduzierten und oxidierten Nicotinamidadenin-dinucleotids bei 260 nm Influence of pH, Temperature and Polarity of the Solvent on the Absorption of NADH+ and NADH at 260 nm
	Reference	Z. Naturforsch. 35c, 76—7 (1980); eingegangen am 30. März/26. Septem ber 1979
	Published	1980
	Keywords	AD H, UV-Absorption, Tem perature, Methanol, Enthalpy of Conform ational Change
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0076.pdf
	Identifier	ZNC-1980-35c-0076
	Volume	35

15	Author	E. Klamann, F. Lingens	Requires cookie*
	Title	Degradation of (—)-Ephedrine by Pseudomonas putida Detection of (—)-Ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis
	Abstract	(—)-Ephedrine, (—)-Ephedrine: N A D +-oxidoreductase, Pseudomonas putida, Arthrobacter globiformis A bacterium utilizing the alkaloid (-)-ephedrine as its sole source o f carbon was isolated by an enrichment-culture technique from soil supplemented with 4-benzoyl-l,3-oxazolidinon-(2). The bacterium was identified as Pseudomonas putida by morphological and physiological studies. The following metabolites were isolated from the culture fluid: methylam ine, formaldehyde, methyl-benzoylcarbinol (2-hydroxy-1-oxo-l-phenylpropane), benzoid acid, pyrocatechol and cis, cis-muconic acid. A pathway for the degradation o f (-)-ep h ed rin e by Pseudomonas putida is proposed and compared with the degradative pathway in Arthrobacter globiformis. The enzyme, which is responsible for the first step in the catabolism of (-)-ep h ed rin e could be demonstrated in extracts from Arthrobacter globiformis. This enzyme catalyses the dehydrogena tion of (—)-ephedrine yielding phenylacetylcarbinol/m ethylbenzoylcarbinol and methylam ine. It requires N A D + as cofactor and exhibits optimal activity at pH 11 in 0.1 M glycine/N aO H buffer. The K m value for (—)-ephedrine is 0.02 mM and for N A D + 0.11 m M , respectively. No rem arkable loss of activity is observed following treatm ent with EDTA. The enzyme has been shown to react with a wide range o f ethanolamines. A slight enrichment was obtained by am m onium sulphate precipitation. The name (—)-ephedrine: N A D +-oxidoreductase (deam inating) is proposed.
	Reference	Z. Naturforsch. 35c, 80—8 (1980); received October 24 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0080.pdf
	Identifier	ZNC-1980-35c-0080
	Volume	35

16	Author	Peter Flesch, Lutz Robbel	Requires cookie*
	Title	Über die Bildung von Cholesterin durch Botrytis cinerea nach Lanosterinzugabe The Production of Cholesterol by Botrytis cinerea after Addition of Lanosterol
	Abstract	The fungus Botrytis cinerea, which is found on the grapes, is able to produce cholesterol after addition of lanosterol to the culture medium. The identification o f cholesterol is carried out with different analytical methods including mass spectrometry. U nder the same conditions ergosterol arises from squalene and not cholesterol.
	Reference	Z. Naturforsch. 35c, 88—9 (1980); eingegangen am 16.
	Published	1980
	Keywords	Mycosterols, Lanosterol, Cholesterol, Botrytis cinerea
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0088.pdf
	Identifier	ZNC-1980-35c-0088
	Volume	35

17	Author	M. Wink, T. Hartmann, L. Witte	Requires cookie*
	Title	Enzymatic Synthesis of Quinolizidine Alkaloids in Lupin Chloroplasts
	Abstract	The enzymatic sequence responsible for the biosynthesis o f tetracyclic quinolizidine alkaloids could be localized in chloroplasts isolated from Lupinus polyphyllus leaves and L. albus seedlings by differential centrifugation. U pon feeding of cadaverine to isolated chloroplasts lupanine is produced as the m ain alkaloid. Chloroplasts treated with digitonine produce sparteine and 17-oxosparteine instead o f lupanine, thus indicating that the biosynthetic sequence is interrupted. The intermediacy of 17-oxosparteine could be confirmed since exogeneous 17-oxosparteine is con verted into lupanine by intact chloroplasts. 17-Oxosparteine synthase (see Z. N aturforsch. 34 c, 704 1979) the key enzyme of quinolizidine alkaloid biosynthesis could be solubilized from chloro plasts treated with detergents or osmotic shock.
	Reference	Z. Naturforsch. 35c, 93—9 (1980); received Septem ber 26 1979
	Published	1980
	Keywords	Quinolizidine Alkaloids, Enzymatic Synthesis, Isolated Chloroplasts, Lupinus polyphyllus
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0093.pdf
	Identifier	ZNC-1980-35c-0093
	Volume	35

18	Author	Erika Wax, Wolfgang Lockau	Requires cookie*
	Title	Stoichiometric Photophosphorylation in Thylakoids from the Blue-Green A\ga, Anabaena variabilis
	Abstract	Cyanobacterium, Thylakoids, Photophosphorylation, P /e 2 Ratio, pH G radient A method is described for the preparation o f thylakoids from the blue-green alga Anabaena variabilis which exhibit photosynthetic control. The thylakoids can be stored in liquid N 2 with little loss in activity. P /e 2 ratios (num ber of ATP molecules formed per pair o f electrons transported) have been determ ined for partial reactions o f the photosynthetic electron transport chain. Electron transport from water to an electron acceptor o f photosystem I is coupled to phos phorylation with a P /e 2 ratio o f 0.9— 1.2, from water to electron acceptors of photosystem II with ratios of 0 .2 1 -0 .3 , and oxidations o f hydrogen carriers by photosystem I with ratios of 0.3 — 0.35. Electron transport in these assay systems generates a proton gradient across the thylakoid m em brane (acid inside), which is decreased by the substrates o f phosphorylation and by uncouplers.
	Reference	Z. Naturforsch. 35c, 98 (1980); received October 4 1979
	Published	1980
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	Identifier	ZNC-1980-35c-0098
	Volume	35

19	Author	K. Tempel	Requires cookie*
	Title	Unprogrammierte DNA-Synthese (DNA-Reparatur) in Milz-und Thymuszellen der Ratte nach Einwirkung von UV-Licht, Röntgenstrahlen oder Methylmethansulfonat in vitro Unscheduled DNA Synthesis (DNA-Repair) within Splenic and Thymic Cells of the Rat under the Influence of UV-Light, X-Irradiation and/or Methyl-methanesulfonate
	Abstract	D NA -Repair, Splenocytes, Thymocytes, Irradiation, M ethyl-M ethanesulfonate Unscheduled D NA synthesis (UDS) o f splenic and thymic cells of the rat has been stim ulated in vitro by UV-light (8 — 128 J x m -2), X-rays (120—3480 rd), methyl-methanesulfonate (MMS), and/or a com bination of UV-light and X -irradiation. The height o f U DS-induced stim ulation o f incorporation of [3H] thym idine into splenic and thymic cell DNA at saturation doses o f UV-light (splenic cells: 8, thym ic cells: 96 J x m -2) or X -irradiation (splenic cells: 960, thym ic cells: ~ 3480 rd) suggest that the greater sensitivity of T-cells (represented by thymic cells) towards UV-light and the greater sensitivity of B-cells (represented by splenic cells) towards X-rays can be explained — at least partly — in terms of less efficient excision repair systems.
	Reference	Z. Naturforsch. 35c, 106—111 (1980); eingegangen am 21. September/22. O ktober 1979
	Published	1980
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	Identifier	ZNC-1980-35c-0106
	Volume	35

20	Author	A. Čihák, J. M. Adar, J. Veselý	Requires cookie*
	Title	Effect of 5-Aza-2'-deoxycytidine on Antibody Formation and DNA Synthesis in Rat Spleen
	Abstract	5-Aza-2'-deoxycytidine, Spleen, Antibody Formation 5-Aza-2'-deoxycytidine which is preferentially taken up by the lymphatic tissue and is in corporated into D NA strongly affects the ability of the immune system to synthesize IgG anti bodies against sheep red blood cells without affecting IgM antibody formation. A single dose of the drug results in a prolonged inhibition persisting 14 days after the secondary immunization. The inhibitory effect is dose-dependent and is maximal when 5-aza-2'-deoxycytidine is given 2 days after sheep erythrocytes. The drug affects the utilization o f thymidine for the synthesis of DNA in the spleen; under certain conditions the enhancement of the rate o f DNA synthesis in the spleen has been observed.
	Reference	Z. Naturforsch. 35c, 112—116 (1980); received August 17 1979
	Published	1980
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	TEI-XML for	default:Reihe_C/35/ZNC-1980-35c-0112.pdf
	Identifier	ZNC-1980-35c-0112
	Volume	35

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