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2001 (183)
1Author    V. Eneta Ivanova3, M. Onica, O. Riolb, M. M. Aria-Jesus, A. Ontesb, G. Ngela, Jesus ArcíabRequires cookie*
 Title    Secondary Metabolites from a Streptomyces Strain Isolated from Livingston Island, Antarctica  
 Abstract    u in eab a Institute o f M icrobiology, Bulgarian A cad em y o f Sciences, "A cad. G .B on ch ev-S tr.", B1.26, 1113 Sofia, Bulgaria b U niversity o f B arcelon a, Faculty o f Pharmacy, D ep artm en t o f M icrobiology, c/Juan X X III s/n, 08028 B arcelona, Spain * A uthor for correspon dence and reprint requests Z. N aturforsch. 5 6 c , 1 -5 (2001); received S ep tem ber 6 /N o v em b er 6 , 2000 S treptom yces sp. 1010, Secondary M etab olites The producing strain Streptom yces sp. 1010 w as isolated from a sh allow sea sed im en t from the region o f Livingston Island, A ntarctica. From the culture broth o f this strain naturally active secondary m etab olites w ere isolated identical to phthalic acid diethyl ester (C 1 2 H 1 4 0 4, MW. 222); 1, 3-bis (3-p h en oxyp h en oxy)b en zen e (C 3 0 H 2 2 O 4 , MW.446); h exan ed ioic acid d ioc­ tyl ester (C2 2 H 4 2 O 4 , M W .370) and the new substance 2-am ino-9, 13 -dim ethyl h eptad ecanoic acid (C 1 9 H 3 9 N O 2 , M W .313). T hese com poun ds rep resent diverse classes o f chem ical struc­ tures and provide evid en ce for the untapped biosyn th etic poten tial o f m arine bacteria from A ntarctica. 
  Reference    Z. Naturforsch. 56c, 1 (2001) 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0001.pdf 
 Identifier    ZNC-2001-56c-0001 
 Volume    56 
2Author    Requires cookie*
 Title    /\_yr  
 Abstract    Fig. 1. C h em ical structures o f C n -com p ou n d s identified in D ic ty o p teris oils. 
  Reference    Z. Naturforsch. 56c, 6 (2001) 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0006.pdf 
 Identifier    ZNC-2001-56c-0006 
 Volume    56 
3Author    Requires cookie*
 Title    Characterization of the Polyphenolic Composition of Purple Loosestrife (Lythrum salicaria)  
 Abstract    Jussi-Pekka R a u h a 3, Jean-Luc W olfenderb, Ju h a-P ekka Salm inenc, Kalevi Pihlajac, K urt H o stettm an n b and H eikki V uorela3-* a D epartm en t o f Pharmacy, D ivision o f Pharm acognosy, P. O .B ox 56, F IN -00014 U n iversity o f H elsinki, Finland. Fax: + 3 5 8 -9 -1 9 1 59 578. E-m ail: heikki.vuorela@ helsinki.fi b Institut de P harm acognosie et P hytochim ie, U n iversite de L ausanne, BEP, CH -1015 Lausanne, Sw itzerland c D epartm en t o f Chemistry, Laboratory o f Physical Chem istry, F IN -20014 U n iversity o f Turku, Finland * A uthor for correspon dance and reprint requests Z . Naturforsch. 5 6 c , 1 3 -2 0 (2001); received A ugust 22/S ep tem b er 14, 2000 L yth ru m salicaria, Flavonoids, P henolic A cids, Tannins P henolic com p ou n d s o f purple loosestrife (L yth ru m salicaria L.) w ere analysed by the use o f liquid chrom atography -mass spectrom etry (L C /M S) eq u ip p ed w ith atm osp heric pressure chem ical ionisation (A P C I) and electrospray ion isation (E S I). The presen ce o f vitexin and orientin as w ell as their isom ers, isovitexin and isoorien tin , w ere con firm ed using ion trap m ultiple stage L C /M S3 analysis. Several ph en olic acids and tannins w ere also d etected . E llagi-tannins, vescalagin and pedunculagin, are reported from the plant for the first tim e. 
  Reference    Z. Naturforsch. 56c, 13 (2001) 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0013.pdf 
 Identifier    ZNC-2001-56c-0013 
 Volume    56 
4Author    Requires cookie*
 Title    Quinolizidine Alkaloid Profiles of  
 Abstract    Lupinus varius orientalis, L. albus albus, L. hartwegii, and L. densiflorus Assem El-Shazlya, A bdel-M onem M. A te y a 3 and M ichael W inkb * a D epartm en t o f Pharm acognosy, Faculty o f Pharmacy, Z agazig University, Zagazig, Egypt b Institut für Pharm azeutische B io lo g ie der U n iversität, Im N eu en h eim er Feld 364, 69120 H eidelberg, G erm any. Em ail: m ichael.w ink@ urz.uni-heidelberg.de * Author for correspon dence and reprint requests Z. Naturforsch. 5 6 c, 2 1 -3 0 (2001); received S ep tem b er 2 0 /0 c to b e r 25, 2000 Q uinolizidine A lkaloids, B iological A ctivity A lk aloid profiles o f tw o L u pin u s sp ecies grow ing naturally in Egypt (L . albus albus [sy n ­ on ym L. term is], L. varius o rien talis) in addition to tw o N e w W orld sp ecies (L . h artw egii, L. den sifloru s) which w ere cultivated in E gypt w ere stu died by capillary G L C and G LC -m ass spectrom etry w ith respect to quinolizidine alkaloids. A lto g e th er 44 quinolizidine, bipiperidyl and proto-indole alkaloids w ere identified; 29 in L. albus, 13 in L. varius orientalis, 15 in L. hartw egii, 6 in L. densiflorus. Som e o f th ese alkaloid s w ere identified for the first tim e in these plants. T he alkaloidal patterns o f various plant organs (leaves, flowers, stem s, roots, pods and seed s) are docu m en ted . Screening for antim icrobial activity o f these plant extracts dem onstrated substantial activity against C an dida albicans, A spergillu s fla vu s and Bacillus subtilis. 
  Reference    Z. Naturforsch. 56c, 21 (2001) 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0021.pdf 
 Identifier    ZNC-2001-56c-0021 
 Volume    56 
5Author    Requires cookie*
 Title    Coprinol, a New Antibiotic Cuparane from a Coprinus Species  
 Abstract    M artin Johansson3, O lov S te rn e r3 *, H arald Labischinskib and Timm A n k e c * a D ivision o f O rganic C hem istry 2, C h em ical C enter, U niversity o f Lund, P. O .B ox 124, S-221 00 Lund, S w ed en . Fax: +46 46 222 8209. E-m ail: 01ov.Sterner@ orgk2.lth.se b B ayer AG , P H -R esearch A n tib acterial Therapy I, D -42096 W uppertal c Institut für B io tec h n o lo g ie und W irkstoff-Forschung IBW F e. V.,: +49 631 205 2999. E-m ail: anke@ rhrk.uni-kl.de * A uthors for corresp on d en ce and reprint requests Z. Naturforsch. 56c, 3 1 -3 4 (2001); received O ctob er 23/N ovem b er 6 , 2000 B asid iom ycete, C o p rin u s sp., A n tib acterial A n tib iotic C oprinol, a n ew antibacterial cuparane, was isolated from ferm entations o f a C oprin u s sp. Its biological activities w ere in vestigated and its structure was elucidated by sp ectroscop ic m ethods. The n ew antibiotic exh ib ited activitiy against m ultidrug-resistant G ram -positive bacteria in vitro. Two derivatives w ere syn thesized ent com pound. 
  Reference    Z. Naturforsch. 56c, 31 (2001) 
  Published    2001 
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 Identifier    ZNC-2001-56c-0031 
 Volume    56 
6Author    Requires cookie*
 Title    Volatile Compounds of Cashew Apple (Anacardium occidentale L.)  
 Abstract    B eatriz B icalh o * and C laudia M. R ezende U n iversidade Federal do R io de Janeiro, C entro de T ecnologia, B lo co A , In stituto de Q ufm ica, Lab. 622, Uha do Fundäo. R io de Janeiro -RJ, 2 1 9 4 9 -9 0 0 , Brazil * A uthor for correspondence and reprint requests Z. Naturforsch. 56c, 3 5 -3 9 (2001); received A ugust 22/S ep tem b er 26, 2000 P resent address: U N IC A M P /In stitu to de Q ufm ica, CP 6154, C am pinas -SP, 1 3 0 8 3 -9 7 0 , Brazil. E-mail: beatriz@ iqm .unicam p.br A n acardiu m occidentale L., C ashew A p p le, V olatile C om p oun ds The volatile com pounds o f a largely con su m ed Brazilian cashew apple variety (A n a c a r­ diu m occiden tale L. var. nanum , A n acard iaceae) w ere recovered by headspace extraction or sim ultaneous distillation-extraction. Several com poun ds including esters (29), terp en es (16), hydrocarbons (9), carboxylic acids (7), aldehyd es (7), alcoh ols (3), k eto n es (2), lacton es (2) and norisoprenoids (1) w ere characterized and qu antified by gas ch ro m a to g ra p h y -m a ss spectrom etry analyses. 
  Reference    Z. Naturforsch. 56c, 35 (2001) 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0035.pdf 
 Identifier    ZNC-2001-56c-0035 
 Volume    56 
7Author    G. Uddadarangavvanahally, K. Jayaprakasha, P. Radeep, S. Negi, ChinnaswamRequires cookie*
 Title    Chemical Composition of Turmeric Oil -A Byproduct from Turmeric Oleoresin Industry and Its Inhibitory Activity against Different Fungi  
 Abstract    A n an d h aram ak rish n an and K urian K. Sakariah* H um an R esource D ev elo p m en t, C entral F ood T echnological R esearch Institute, M ysore-570 013, India. Fax: 0 8 2 1 -5 1 6 3 0 8 . E-m ail: gkjp@ yahoo.com * A uthor for correspon dence and reprint requests Z. Naturforschung. 56c, 4 0 -4 4 (2001); received O ctob er 10/N ovem ber 10, 2000 Turmeric O il, A rom atic Turm erone, A n tifu ngal A ctivity Curcum in, the y ellow coloring pigm ent o f turm eric is produced industrially from turmeric oleoresin . The m other liquor after isolation o f curcum in from oleoresin know n as curcumin rem oved turm eric o leoresin (C R T O) w as extracted three tim es with «-h exan e at room tem ­ perature for 30 m in to obtain turm eric oil. The turm eric oil w as subjected to fractional distil­ lation under vacuum to get tw o fractions. T hese fractions w ere tested for antifugal activity against A spergillu s flavus, A . parasiticus, Fusarium m o n ilifo rm e and Penicillium digitatum by spore germ ination m eth od. Fraction II was found to be m ore active. The chem ical con stitu ­ ents o f turm eric oil, fraction I and fraction II w ere d eterm ined by G C and identified by G C-MS. A rom atic turm erone, turm erone and curlone w ere major com poun ds present in fraction II along with other o xygen ated com pounds. 
  Reference    Z. Naturforsch. 56c, 40 (2001) 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0040.pdf 
 Identifier    ZNC-2001-56c-0040 
 Volume    56 
8Author    C. Arm, Rtín-C Ordero, M.Ariana Reyes, M. Jesús, A. Yuso, M. V. Ictoria ToroRequires cookie*
 Title    Cytotoxic Triterpenoids from Erica andevalensis  
 Abstract    D ep artam en to de Farm acologfa, Facultad de Farmacia, c/ P. Garcia G onzalez, 41012 Sevilla, E spana. Fax: 0034/5/4233765. E-m ail: victoria@ fafar.us.es * A uthor to for correspon dance and reprint request Z. N aturforsch. 56c, 4 5 -4 8 (2001); received A ugust 4/O ctob er 25, 2000 H um an C ancer C ell Lines, T riterpenoids, U rsolic A cid T he cytotoxic activity o f tw o p entacyclic triterpenoids (ursolic acid and a-am yrin e) isolated from the m eth an olic extract o f the aerial parts from E rica andevalensis, w h ose structures have b een estab lish ed on the basis o f sp ectroscop ic and chem ical evid en ce, has b een assessed against three hum an cancer cell lines, T K -10 (renal adenocarcinom a), M CF-7 (breast a d e n o ­ carcinom a) and U A C C -62 (m ela n o m a), recom m en d ed by N C I (N ational C ancer In stitute) and w e also evalu ated the antim itotic effect in root m eristem atic cells o f A lliu m cepa. U rsolic acid w as foun d to p o ssess the high est cytotoxic activity. 
  Reference    Z. Naturforsch. 56c, 45 (2001) 
  Published    2001 
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 Identifier    ZNC-2001-56c-0045 
 Volume    56 
9Author    Nektarios Kalpoutzakis, Sofia Aligiannis, Ioanna Mitaku, Catherine Chinou, Alexios-Leandros Harvala, SkaltsounisRequires cookie*
 Title    Eleftherios  
 Abstract    The antimicrobial activity of fifteen semisynthetic labdane-type diterpenes derived from the two major natural compounds 3 and 4 of the resin "ladano" of Cistus creticus is reported. The chloroethyl carbamidic esters 15 and 20 showed the strongest antimicrobial activity against Gram (+), Gram (-) bacteria and pathogenic fungi. 
  Reference    Z. Naturforsch. 56c, 49—52 (2001); received September 20/November 10 2000 
  Published    2001 
  Keywords    Cistus creticus, Labdane-Type Diterpens, Antimicrobial 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0049.pdf 
 Identifier    ZNC-2001-56c-0049 
 Volume    56 
10Author    Em Ília Breierová3, Ján Šajbidor6, Martin LamačkabRequires cookie*
 Title    The Influence of Newly Synthesised Fenpropimorph Derivatives on Some Pathogen Yeasts  
 Abstract    The effect of minimum inhibitory concentrations (MICs) of six novel fenpropimorph deri­ vatives on lipid and sterol composition of Candida albicans, Cryptococcus neoformans, Malas-sezia pachydermatis and Malassezia furfur was investigated. The MICs for the most effective derivatives were found in the range from 3.7 to 56.7 | x m and were 2 -3 times lower compared to the commercial fungicide bifonazol. The more efficient fenpropimorph derivatives were the piperidine derivative for C. albicans and the allylamine derivative for Cr. neoformans, M. pachydermatis and M. furfur . The inhibitor in the growth medium reduced the unsaturation index of the total lipid content in M. furfur and C. 
  Reference    Z. Naturforsch. 56c, 53—5 (2001); received July 28/September 12 2000 
  Published    2001 
  Keywords    Fenpropimorph Derivatives, Ergosterol, Lipids 
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 Identifier    ZNC-2001-56c-0053 
 Volume    56 
11Author    Fatih Demirci3, E. Kirim, Betül Demirci3, Yoshiaki Nom, KemalH. Üsnü, Can BaeraRequires cookie*
 Title    Screening of Biotransformation Products of Carvone Enantiomers by Headspace-SPME/GC-MS ¥  
 Abstract    Microbial Transformation, Carvone Enantiomers, Headspace-SPME/GC-MS In the course of our continuing work on transformation of monoterpenes by microorga­ nisms, the biotransformation of (+)-and (-)-carvone was carried out. The metabolites formed during microbial transformations were screened using a simple, rapid and efficient technique: Headspace-solid phase microextraction the application of this technique are described. 
  Reference    Z. Naturforsch. 56c, 58—64 (2001); received September 26/November 2 2000 
  Published    2001 
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 Identifier    ZNC-2001-56c-0058 
 Volume    56 
12Author    OliverO. Tte, Andreas Pachten, Frauke Hein, Wolfgang BarzRequires cookie*
 Title    Early Elicitor-Induced Events in Chickpea Cells: Functional Links between Oxidative Burst, Sequential Occurrence of Extracellular Alkalinisation and Acidification, K+/H + Exchange and Defence-Related Gene Activation  
 Abstract    Elicitation of cultured chickpea (Cicer arietinum L.) cells stimulates a signal transduction pathway leading to several rapid responses: (1) oxidative burst, (2) extracellular alkalinisa­ tion, (3) extracellular acidification, (4) transient K+ efflux, and (5) activation of defence related genes all within 2 hours. Induced genes are encoding acidic and basic chitinases, a thaumatin-like protein and isoflavone reductase. All these elicitor-induced responses are in­ hibited by the Ser/Thr protein kinase inhibitor staurosporine and the anion channel blocker anthracene-9-carboxylic acid but stimulated by the Ser/Thr protein phosphatase 2A inhibitor cantharidin. The oxidative burst leads to a transient extracellular H2 0 2 accumulation which seems to be preceded by 0 2~ production, indicating dismutation of 0 2~ to H2 0 2. The oxida­ tive burst is accompanied by transient alkalinisation of the culture medium which is followed by long-lasting extracellular acidification. An 80 percent inhibition of the alkalinisation after complete inhibition of the H2 0 2 burst with diphenylene iodonium indicates that the elicitor induced increase of extracellular pH is mainly based on a proton consumption for 0 2~ dismutation. A simultaneous deactivation of the plasma membrane H+-ATPase during oxida­ tive burst and extracellular alkalinisation is also suggested. The elicitor-stimulated extracellu­ lar acidification is inhibited by the plasma membrane H+-ATPase inhibitor N, N'-dicyclohex-ylcarbodiimide assuming a reactivation of the H+-ATPase 25 min after elicitation. Extracellular acidification seems not to be necessary for elicitor-induced activation of defence related genes. Opposite modulation of K+ and proton fluxes after elicitation and/or treatment with the H +-ATPase effectors fusicoccin or N, N'-dicyclohexylcarbodiimide indicate that the elicitor induced transient K+ efflux is regulated by a K+/H+ exchange reaction. 
  Reference    Z. Naturforsch. 56c, 65—76 (2001); received August 29 2000 
  Published    2001 
  Keywords    Cicer arietinum, Defence Related Gene Activation, Extracellular Acidification, Oxidative Burst 
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 Identifier    ZNC-2001-56c-0065 
 Volume    56 
13Author    Vijay Kumar Sharmab, Christer Jensen3, Anders Johnsson3Requires cookie*
 Title    Phase Response Curve for the Ultradian Rhythm of the Lateral Leaflets of Desmodium gyrans Using DC Current Pulses  
 Abstract    In the present study the leaf movement rhythm was perturbed by the application of DC current pulses (15 [xA, 10 seconds, voltage applied: 10 V) to the upper part of the pulvinus, passing through the pulvinus and its stalk. The pulses were applied at four different positions of the leaflets: when the leaves were at the lowermost position, when moving up, at the uppermost position and when moving down. The pre-perturbed and the post-perturbed rhythms were compared. We found that the rhythms were shifted in phase and the phase shifts observed at the four different positions of the leaflets were significantly different in magnitude as well as direction. Furthermore, we could also observe phase advances, which is in contrast to an earlier finding. A phase response curve (PRC) was constructed to illustrate the sensitivity of the oscillating leaflet system to DC pulses. Substantial delays of about 50 s (as compared to the period of about 200 s) were obtained when pulses were administered at the lowermost position and when leaflet were moving upwards, while advances or no phase shifts were recorded in the uppermost position and when leaflet were moving down respectively. 
  Reference    Z. Naturforsch. 56c, 77—81 (2001); received September 25/October 25 2000 
  Published    2001 
  Keywords    Rhythm, Leaflet, Desmodium 
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 Identifier    ZNC-2001-56c-0077 
 Volume    56 
14Author    Ahm Ed, G. Hegazi, FatenK. Abd, El HadyRequires cookie*
 Title    Egyptian Propolis: 1-Antimicrobial Activity and Chemical Composition of Upper Egypt Propolis  
 Abstract    The antimicrobial activity of four propolis samples collected from Upper Egypt against Staphylococcus aureus; Escherichia coli and Candida albicans was evaluated. There was a variation in the antimicrobial activity according to the propolis origin. Banisweif propolis showed the highest antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, but Fayoum propolis had moderate activity against all tested pathogens. Propolis collected from Assiut and Souhag gave lower antimicrobial activity. Propolis samples were investigated by GC/MS, 71 compounds were identified, 14 being new for propolis. Banisweif propolis is characterized by the presence of 7 caffeate esters and 4 triterpenoids. Fayoum propolis showed the highest amount of lactic acid and the presence of 3 chalcones. But Assiut propolis is characterized by the presence of 4 prenylated coumar-ates. Souhag propolis is characterized by the presence of 5 aliphatic dicarboxylic acids and some other new compounds to propolis. 
  Reference    Z. Naturforsch. 56c, 82—88 (2001); received July 24/October 9 2000 
  Published    2001 
  Keywords    Propolis, Polyphenols, Antimicrobial Activity 
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 Identifier    ZNC-2001-56c-0082 
 Volume    56 
15Author    Reinhold DemRequires cookie*
 Title    Influence of Food and Larval Age on the Defensive Chemistry of Satumia pyri  
 Abstract    Scolus secretions and hemolymph of caterpillars of Satumia pyri fed with two different foodplants (Crataegus m onogyna, Prunus spinosa) were chemically analyzed and their chemi­ cal similarities determined. The secondary-compound patterns obtained for the two body fluids showed no significant differences when compared between the two groups of alterna­ tively fed last-instar larvae. Thus, the composition of these fluids of full-grown caterpillars is not influenced by the larval diet. However, younger larvae on P. spinosa revealed a diversity of compounds differing significantly from that of larger caterpillars fed with either C. m ono­ gyna (both body fluids) or P. spinosa (hemolymph only). This indicates that, on the one hand, the hemolymph composition is adapted to the changing physiological requirements of the given instars whereas, on the other hand, the defensive mixtures remain unaltered in the late larval instars due to a constant spectrum of potential enemies. 
  Reference    Z. Naturforsch. 56c, 89—94 (2001); received September 12/October 18 2000 
  Published    2001 
  Keywords    Chemical Defense, Saturniidae, Secondary Compounds 
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 Identifier    ZNC-2001-56c-0089 
 Volume    56 
16Author    CarlosL. Céspedes3, M. Ariano Martinez-Vázquez3, JoseS. Calderón3, JuanR. Salazar3, EduardoA. RandabRequires cookie*
 Title    Insect Growth Regulatory Activity of Some Extracts and Compounds from Parthenium argentatum on Fall Armyworm Spodoptera frugiperda  
 Abstract    Argentatins, Insect Growth Regulators, Acetylcholinesterase The methanolic extract from aerial parts of Parthenium argentatum, afforded argentatin A and B. These compounds were evaluated for their effect on the fall armyworm (Spodoptera frugiperda). Toosendanin, a commercial insecticide derived from Melia azedarach was used as positive control. When tested for activity, using neonate larvae into the no-choice artificial diet bioassays, argentatin A, argentatin B and methanol extract caused significant growth inhibitory activity with GC50 of 17.8, 36.1 and 6.4 ppm at 7 days, respectively, and increased the development time of surviving larvae in a concentration-dependent manner with RGI values of 0.40, 0.60 and 0.26, at 25.0, 25.0 and 5.0 ppm. respectively. In addition, it was pos­ sible to observe in most of the treated groups a significant delay in the time of pupation, adult emergence and deformities. Acute toxicity against adults of S. frugiperda was also found, MeOH extract had the most potent activity with LD50 value of 3.10 ppm. In addition, MeOH extract and argentatin A caused acetylcholinesterase inhibition of 93.7% and 90.0%, at 5.0 and 50.0 ppm, respectively; whereas argentatin B had only slight inhibitory activity. Therefore, the MeOH extract was identified as insecticidal extract from P. argentatum with activity at concentrations above 15.0 ppm. 
  Reference    Z. Naturforsch. 56c, 95—105 (2001); received August 30/0ctober 17 2000 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0095.pdf 
 Identifier    ZNC-2001-56c-0095 
 Volume    56 
17Author    Kerstin Fabian3, TimmA., Olov Sterner6-Requires cookie*
 Title    Mariannaeapyrone -a New Inhibitor of Thromboxane A 2 Induced Platelet Aggregation  
 Abstract    Mariannaea elegans, Mariannaeapyrone, Platelet Aggregation Mariannaeapyrone ((£,)-2-(l,3,5,7-tetramethyl-5-nonenyl)-3,5-dimethyl-6-hydroxy-4//-py-ran-4-one) is a new fungal metabolite isolated from fermentations of the common mycophilic deuteromycete Mariannaea elegans. The chemical structure of the 4-pyrone was determined by spectroscopic techniques. Mariannaeapyrone is a selective inhibitor of the thromboxane A2 induced aggregation of human platelets, whereas only weak cytotoxic and antimicrobial effects could be observed. 
  Reference    Z. Naturforsch. 56c, 106—110 (2001); received September 4/October 6. 2000 
  Published    2001 
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 Identifier    ZNC-2001-56c-0106 
 Volume    56 
18Author    Meinrad Boll, LutzW D Weber, Eberhard Becker, Andreas StampflRequires cookie*
 Title    Pathogenesis of Carbon Tetrachloride-Induced Hepatocyte Injury Bioactivation of CC14 by Cytochrome P450 and Effects on Lipid Homeostasis  
 Abstract    The CCl4-induced development of liver damage was studied in monolayer cultures of pri­ mary rat hepatocytes: (1) CC14 caused accumulation of triglycerides in hepatocytes following cytochrome P450 induction with ß-naphthoflavone or metyrapone. Ethanol or a high dose of insulin plus triio­ dothyronine had the same effect. (2) CC14 increased the synthesis of fatty acids and triglycer­ ides and the rate of lipid esterification. Cholesterol and phospholipid synthesis from acetate was also increased. (3) CC14 reduced ß-oxidation of fatty acids as assessed by C 0 2-release and ketone body formation. Hydrolysis of triglycerides was also reduced. (4) The content of unsaturated fatty acids in microsomal lipids was decreased by almost 50% after incubation with CCI4, while saturated fatty acids increased slightly. (5) CC14 exerted a pronounced inhib­ itory effect on the exocytosis of macromolecules (albumin), but did not affect secretion of bile acids from hepatocytes. 
  Reference    Z. Naturforsch. 56c, 111—121 (2001); received July 28/September 14 2000 
  Published    2001 
  Keywords    Liver Damage, Carbon Tetrachloride, Cytochrome P450 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0111.pdf 
 Identifier    ZNC-2001-56c-0111 
 Volume    56 
19Author    Miroslawa Ferens-Sieczkowska3, Mariusz 01czakbRequires cookie*
 Title    Carbohydrate Structures of Haptoglobin in Sera of Healthy People and a Patient with Congenital Disorder of Glycosylation  
 Abstract    Haptoglobin, Glycosylation, Congenital Disorder of Glycosylation Haptoglobin is one of acute phase glycoproteins often used as markers in glycopathology studies. In this work the oligosaccharide structures of haptoglobin from 'healthy' subjects have been studied in detail, taking into consideration the possible dependence of glycosyla­ tion on the phenotype. About 75% of charged haptoglobin glycans were of biantennary complex structure, and some of them lacked one terminal sialic acid molecule. Triantennary structures made up almost 25% of the charged glycans pool, and highly branched tetrasialy-lated oligosaccharides did not exceed 1%. The main difference between haptoglobin derived from the sample of pooled 44 sera and from the 2 -2 phenotype individual concerned the relative content of trisialylated oligosaccharide with one 2 -3 linked sialic acid residue. The oligosaccharide profile of haptoglobin derived from serum of a patient suffering from con­ genital disorder of glycosylation was compared to 'healthy' controls. It was shown, that four main glycans are identical in patient and 'normal' haptoglobins. Some alterations were found in the relative content of mono-, bi-, and trisialylated glycans as well as in the appearance of some tracely abundant oligosaccharides in haptoglobin of the patient with congenital dis­ order of glycosylation. 
  Reference    Z. Naturforsch. 56c, 122—131 (2001); received August 30/0ctober 18 2000 
  Published    2001 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0122.pdf 
 Identifier    ZNC-2001-56c-0122 
 Volume    56 
20Author    Stylianos TsakirisRequires cookie*
 Title    Effects of L-Phenylalanine on Acetylcholinesterase, (Na+,K+)-ATPase and Mg2+-ATPase Activities in Adult Rat Whole Brain and Frontal Cortex  
 Abstract    The effect of different L-phenylalanine (Phe) concentrations (0.12-12.1 m M) on acetylcho­ linesterase (AChE), (Na+,K+)-ATPase and Mg2+-ATPase activities was investigated in ho-mogenates of adult rat whole brain and frontal cortex at 37 °C. AChE, (Na+,K+)-ATPase and Mg2+-ATPase activities were determined after preincubation with Phe. AChE activity in both tissues showed a decrease up to 18% (p<0.01) with Phe. Whole brain Na+,K+-ATPase was stimulated by 30-35% (p<0.01) with high Phe concentrations, while frontal cortex Na+,K+-ATPase was stimulated by 50-55% (pcO.OOl). Mg2+-ATPase activity was increased only in frontal cortex with high Phe concentrations. It is suggested that: a) The inhibitory effect of Phe on brain AChE is not influenced by developmental factors, while the stimulation of Phe on brain Na+,K+-ATPase is indeed affected; b) The stimulatory effect of Phe on rat whole brain Na+,K+-ATPase is decreased with age; c) Na+,K+-ATPase is selectively more stimulated by high Phe concentrations in frontal cortex than in whole brain homogenate; d) High (toxic) Phe concentrations can affect Mg2+-ATPase activity in frontal cortex, but not in whole brain, thus modulating the amount of intracellular Mg2+. 
  Reference    Z. Naturforsch. 56c, 132—137 (2001); received September 4/October 4 2000 
  Published    2001 
  Keywords    Acetylcholinesterase, (Na+, K+)-, Mg2 +-ATPase, L-Phenylalanine 
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 TEI-XML for    default:Reihe_C/56/ZNC-2001-56c-0132.pdf 
 Identifier    ZNC-2001-56c-0132 
 Volume    56 
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